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September 1931

THE GANGLIONEUROMAS OF THE CENTRAL NERVOUS SYSTEM

Author Affiliations

PHILADELPHIA

From the Neurosurgical Clinic and Laboratory of Dr. C. H. Frazier, University Hospital, Philadelphia.

Arch NeurPsych. 1931;26(3):501-523. doi:10.1001/archneurpsyc.1931.02230090034004
Abstract

Among the confused group of tumors described as neuromas, one subclass stands out in well defined relief. This is the class that has been variously described as ganglioneuroma (Bailey and Cushing), ganglioglioma (Perkins) and ganglioglioneuroma (Bielschowsky). Despite the difference in conception, which seems to be indicated by the varied terminology, these tumors constitute a well defined group with well defined characteristics. They are found in the cerebrospinal nerves and ganglia, in the sympathetic system, and most rarely in the central nervous system. In the latter situation only a few such tumors have been reported. We here record a typical ganglioneuroma, the only one in a large series of cases of tumor of the brain in the series of Dr. C. H. Frazier in the University Hospital, Philadelphia.

CLASSIFICATION  The first satisfactory attempt to classify the neuromas was made by Virchow1 who differentiated between false and true neuromas. In the

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