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October 1931

THE BLOOD-CEREBROSPINAL FLUID BARRIER IN MANIC-DEPRESSIVE PSYCHOSIS: RATIOS OF DISTRIBUTION OF BROMIDE, CALCIUM, SUGAR AND CHLORIDES

Arch NeurPsych. 1931;26(4):829-844. doi:10.1001/archneurpsyc.1931.02230100147012
Abstract

RATIO OF DISTRIBUTION OF BROMIDE  Most of the methods designed for the study of the barrier between the blood and cerebrospinal fluid depend on the introduction of some foreign substance into the blood and the subsequent determination of the amount that reaches the cerebrospinal fluid. For reasons that we have set forth in detail elsewhere,1 we regard the test devised by Walter2 for estimating the ratio of distribution of bromide in the two fluids as the most useful representative of this type of procedure. Although brought forward only a few years ago, it has already received wide recognition as a serviceable means of approach toward psychiatric problems. To the present time, however, no publications have dealt with a sufficient number of cases of manic-depressive psychosis to allow definite conclusions concerning the ratio of distribution of bromide in that disorder. Our chief purpose in this communication is to set

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