We have felt for some time that the introduction of antimeningococcic serum into the lumbar sac is a relatively ineffective means of treating patients who have meningococcic meningitis, and that the method of introduction at the cistern, though obviously more efficient, still leaves room for much improvement.
Evidence points to the fact that the primary origin of meningococcic meningitis is septicemia. Choroiditis, ventriculitis and meningitis subsequently develop over the cortices and finally about the cord. When lumbar puncture is done and the injection of serum made, the treatment for the process in the sac and about the lower part of the cord is adequate. Even when the serum is mixed with spinal fluid in the syringe as it is introduced, the height to which the serum rises in the spinal subarachnoid space is questionable, and whereas the meninges about the lower part of the cord may have adequate and immediate
Vibber FL, Tartakoff J. BUBBLE TECHNIC TO INCREASE THE EFFICIENCY OF LUMBAR SAC MEDICATION. Arch NeurPsych. 1931;26(5):1058–1059. doi:10.1001/archneurpsyc.1931.02230110156010
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