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February 1932


Author Affiliations


From the Institute of Neurology, Northwestern University Medical School.

Arch NeurPsych. 1932;27(2):375-388. doi:10.1001/archneurpsyc.1932.02230140129010

The present investigation includes three major problems. The first was an attempt to repeat the experiments of Chevassut1 and of Purves-Stewart2 and to demonstrate the presence of a filtrable virus as an etiologic factor in multiple sclerosis. The second was a repetition of work done previously by Brickner,3 who tried to demonstrate the action of a myelolytic ferment in the plasmas of patients suffering from multiple sclerosis. At the same time, the observations were compared with the results of the lipase tests performed by Crandall4 on our own patients in order to find out whether there was any correlation between the amount of lipase present and the degree of demyelinization of the spinal cord of rats. The third problem was an investigation of the inorganic phosphorus content of the serum of patients with multiple sclerosis, which was undertaken with the hope that it might shed light