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May 1932


Author Affiliations

Assistant Professor of Neurology, University of Illinois College of Medicine CHICAGO

From the Division of Neuropathology (service of Dr. Hassin) of the pathology laboratories of the Research and Educational Hospitals of the University of Illinois.

Arch NeurPsych. 1932;27(5):1175-1208. doi:10.1001/archneurpsyc.1932.02230170191006

Histologic examination of the central nervous system in malignant endocarditis reveals a rather common involvement of the brain which is The present study comprises twelve cases of malignant endocarditis that were placed at my disposal by Dr. R. H. Jaffe from his necropsy material at the Cook County Hospital and one case of rheumatic endocarditis from the Research and Educational Hospitals of the University of Illinois. They all showed manifest circumscribed, as well as diffuse, lesions which, though they varied to some extent, had certain common features which will be described.


Case 1.  —Malignant endocarditis of several months' duration following rheumatic endocarditis; glial nodules in the pons, optic thalamus and subcortical white matter; diffuse glial proliferation; areas of rarefaction around blood vessels; degenerative changes of ganglion cells; hyperemia and mild perivascular infiltration of the pons; hyperplasia of the leptomeninges.

History.  —A white man, aged 42, a goldsmith,

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