An attempt is often made to characterize neuropathologic conditions by describing the changes of only one component of the tissue of the central nervous system. Nissl himself was forced to give up the search for specific changes of the nerve cells in different pathologic states, such as intoxications; but even today this search for specific alterations of the ganglion cells continues and claims of their existence are made. In the same way, descriptions of other individual components of the central nervous system tissue have been offered as adequate histopathologic characterization of a pathologic process and as a basis for neurologic distinctions. It is frequently overlooked that each component of the nerve tissue can react only in a limited number of ways, and that in consequence the same reactions may occur in very different conditions in response to very different causes. What is necessary for the delimitation of a histopathologic process
WERTHAM F. SMALL FOCI OF DEMYELINIZATION IN THE CORTEX AND SPINAL CORD IN DIFFUSE SCLEROSIS: THEIR SIMILARITY TO THOSE OF DISSEMINATED SCLEROSIS AND DEMENTIA PARALYTICA. Arch NeurPsych. 1932;27(6):1380–1401. doi:https://doi.org/10.1001/archneurpsyc.1932.02230180109007
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