The frequency of the occurrence of migraine in women as compared with men is a matter of interest because of the relation of this disproportionate sex ratio to the inheritance of migraine.1 Present knowledge of this sex ratio is derived from the reports of clinical cases, as shown in table 1, and shows a preponderance of women over men.
On the other hand, Gowers2 said, "The preponderance of females has been greatly exaggerated," and Crookshank3 has more recently said that "Perhaps men suffer more frequently from true migraine than do women."
This preponderance of women in clinical reports led Jens Smith,4 while concluding that migraine was inherited directly as a dominant trait, at the same time to conclude that it must in some way be sex-linked. He offered as evidence the statement that migraine most frequently descends from mother to daughter, next in frequency from mother
ALLAN W. THE SEX RATIO IN MIGRAINE. Arch NeurPsych. 1932;27(6):1436–1440. doi:https://doi.org/10.1001/archneurpsyc.1932.02230180165010
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