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July 1932


Arch NeurPsych. 1932;28(1):92-111. doi:10.1001/archneurpsyc.1932.02240010100006

This paper has been undertaken with the hope of adding further facts to an already well established knowledge of the neurologic involvement in primary anemia. Considerable material has been accumulated since 1886, when Lietheim1 first described what are known today to be symptoms of subacute combined degeneration of the spinal cord. In spite of this accumulated material, many conflicting opinions exist about points that probably can be established only when larger groups of cases are studied.

This study is based on the routine neurologic examination in 117 cases of proved primary anemia at the Nicollet Clinic of Minneapolis and in seventy-two similar cases at the Minneapolis General Hospital. The examinations have been made during a period of seven years. The patients were not referred for examination because of marked neurologic signs or symptoms, but as a matter of routine hospital and clinic practice. Naturally, many patients were not examined