Survey of the Literature
Effect on Amphibians
Effect on Mammals
Size of Blood Vessel
Blood Pressure
Heart Rate
Autonomic Nervous System
Original Experiments
Experiments During Amytal Anesthesia
Experiments During Ether Anesthesia
Experiments After Recovery from Ether Anesthesia
Effects of Caffeine, on Animals with Low Blood Pressure
Comment
Summary
SURVEY OF THE LITERATURE
The effect of caffeine and its compounds on circulatory phenomena has long been of interest to physiologists, pharmacologists and clinicians. Since the isolation of the drug in 1820 by Runge, research has piled on research, until at present the literature is extensive. Stuhlman and Falck1 not only mentioned this fact, but enumerated fifty-one articles published between 1820 and 1856. Most of the study has been centered on