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Some years ago Professor Sherrington in his "Mammalian Physiology" outlined a method of experimental approach. This has served as a model for similar manuals, but up to the present volume no similar work on experimental pathology has ever been issued. The Handbook is based on a course on experimental pathology given to second year students of medicine in the University of Pennsylvania, and while the book demonstrates the more important problems in general and special pathology which are widely known, a large number of experiments are original with the authors. There is first a general exposition of experimental methods and care of animals; then the subject is divided into experiments in general pathology and special pathology. These include all parts of the body except the nervous system. To neurologists and psychiatrists the book is chiefly of interest in that the endocrine system is dealt with to a limited degree. From