The interest in the cases described in this paper is twofold: (1) They present an unclassified type of heredofamilial disease of the central nervous system; (2) they show singular somatic manifestations associated with the neurologic manifestations. The study was based on examination of the accessible members of a Greek Jewish family. In two generations four members of the family were found who presented neurologic symptoms; one of them was manifestly ill; another showed latent neurologic symptoms, as well as obvious somatic anomalies; the third and fourth manifested chiefly latent neurologic symptoms.
REPORT OF CASES
Case 1.—History.
—Sophie S., aged 16, had parents who were blood relatives, her father being her mother's uncle. She was born at full term, by normal delivery, and weighed 6½ pounds (2,954.35 Gm.). As an infant she was considered "small and weak." Development was somewhat slow. Dentition began at the age of 1 year; she