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This book is divided into three large, general divisions. The first has to do with the new methods of investigation of spirochetes in the tissues of man and animals; the second concerns the problem of dementia paralytica; the third discusses the application of these new methods to the problem of the etiology of multiple sclerosis. Steiner has written a careful analysis of the problem of the cause of multiple sclerosis. He has considered this problem from many points of view, and he is conservative in his conclusions in that he observes that further proof is required to state finally and certainly that the cause of multiple sclerosis is Spirochaeta myelophtora. The illustrations are excellent, and the bibliography is full.