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March 1934

TREATMENT OF DEMENTIA PARALYTICA WITH TYPHOID H ANTIGEN VACCINEREPORT OF TWENTY-FIVE CASES IN WHICH FEVER THERAPY COMBINED WITH THE ADMINISTRATION OF TRYPARSAMIDE WAS USED

Arch NeurPsych. 1934;31(3):579-589. doi:10.1001/archneurpsyc.1934.02250030119006
Abstract

There are two generally accepted forms of treatment for pathologic changes found in dementia paralytica, namely, the production of hyperpyrexia and chemotherapy.

In 1883, Wagner von Jauregg observed the beneficial effect of intercurrent febrile disease in certain mental diseases; thus, fever therapy was suggested. As fever-producing agents he used malaria, tuberculin, Besredka's vaccine and other methods. The year 1917, however, marks the beginning of the epoch in which fever therapy was put into practice on a large scale, von Jauregg then beginning his series of malarial treatments of dementia paralytica. His results, in general, have not been altered appreciably to the present day. Plaut and Steiner, in 1919, used recurrent fever for the treatment of dementia paralytica, but their results were much less striking than those following the use of malaria. Solomon and his associates,1 in 1926, introduced sodoku (rat-bite fever), which has theoretical possibilities equal to those of

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