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April 1934


Author Affiliations

Ann Arbor, Mich.

From the Neuropathologic Laboratory of the State Psychopathic Hospital, University of Michigan.

Arch NeurPsych. 1934;31(4):817-823. doi:10.1001/archneurpsyc.1934.02250040141010

In 1920, C. and O. Vogt1 reported eight cases in which a peculiar syndrome appeared soon after birth. Spasticity, athetoid movements, various extrapyramidal symptoms and frequently paralysis were noted. The striking and most characteristic patho-anatomic feature was revealed by the myelin sheath stains, which showed in the striate bodies a network of apparently new myelinated fibers forming a dark interlacing meshwork, in the interstices of which lighter areas were seen. The gross appearance in the Weigert sections was, because of this extra myelinization, not unlike marble, and for this reason the condition was called by the Vogts status marmoratus. Subsequently, Bielschowsky,2 Meyer3 and Scholz4 reported similar cases. In this country attention has only recently been called to this condition by the paper of Löwenberg and Malamud,5 in which three histologically examined cases and one living patient are described. Like the cases cited in which the

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