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This monograph will be of value not only to those interested in the "blood-cerebrospinal fluid barrier" but to all workers in the field of cerebrospinal fluid chemistry, because of the discussion of the nature of the cerebrospinal fluid and the extensive bibliography.
Walter's method for studying the permeability of the blood-cerebrospinal fluid barrier consists in the determination of the relative concentration of bromide in blood serum and cerebrospinal fluid after the administration of sodium bromide by mouth for five days. He found the concentration of bromide in the blood serum to be about three times that of the bromide in the cerebrospinal fluid, giving a normal permeability quotient of from 2.9 to 3.5. He reports more than four hundred personal observations on the permeability quotient for bromide in various diseases. He found an increased permeability (decreased permeability quotient) in syphilis of the central nervous system, especially in dementia paralytica, and