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Mueller tries to replace the usual objective and purely descriptive view of biologists by the statement of an order of ranks. In the body of the vertebrate, and particularly in the central nervous system, an order of ranks exists in such a manner that the dorsal parts control those on the ventral side, and the cranial parts control those which lie more caudad. The metasyphilitic process prefers those parts of the nervous system which are the highest in rank; this principle is called Kreissotropism (from the Greek word kreisson, the superior). This rule manifests itself in metasyphilis by the preference for the regulating elements of the segments (for the posterior roots in tabes) and by the destruction of the functionally highest parts in the cerebellum, in the subcortex and particularly in the cerebral cortex. New facts can hardly be found in this book.
Struktur und Aufbau der biologischen Ganzheiten.. Arch NeurPsych. 1934;31(6):1362. doi:10.1001/archneurpsyc.1934.02250060248021
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