According to Elwyn,1 fundamental metabolism, which is concerned with the inorganic salts in relation to the vegetative nervous system, is controlled by a center in the hypothalamic region. Schilder2 expressed the belief that this region is significantly related to the affective layer of the personality. The increase of neuromuscular irritability in calcium deficiency has long been known (Loeb3 and Mathews4). Kraus and Zondek5 stated that the effect of an increase in calcium is analogous to that of the action of the sympathetic, and the effect of increased potassium to that of the vagus, system. It would seem much more simple to demonstrate the effects of variations in the calcium content at lower levels of psychobiologic activity, e. g., in a nerve-muscle preparation, with a minimum of variables, than at the higher levels of the personality, e. g., in impulsive, uninhibited behavior, in which the variables
MICHAELS JJ, SEARLE OM. CALCIUM CONTENT OF THE CEREBROSPINAL FLUID, BLOOD SERUM AND SERUM ULTRAFILTRATE: ITS RELATION TO THE CLINICAL FINDINGS IN EIGHTY NEUROPSYCHIATRIC PATIENTS. Arch NeurPsych. 1935;33(2):330–341. doi:10.1001/archneurpsyc.1935.02250140086006
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