The most convincing evidence of the segmental position of disease of the spinal cord is the objective demonstration of a dermatomic level of sensory loss. When such a demonstration is not possible, pain of segmental distribution, localized atrophy and changes in the reflexes may be the deciding factors in determining the site of the lesion.
The autonomic nervous system has contributed little to the diagnostic localization of morbid processes affecting the spinal cord. This little understood system has mystified rather than aided the clinicians, a fact which doubtless is the logical corollary of the meager knowledge of the physiology of that system. This study is an effort to determine whether the sympathetic system can be made to assist in the localization of disease in the spinal cord. When the usual response to stimulation of the sympathetic system is known, a deviation from that norm may be interpreted as due to
CRAIG CB, HARE CC. SWEATING REACTION IN PATIENTS WITH DISEASES OF THE SPINAL CORD: STUDY OF THE REACTION PRODUCED BY THE INJECTION OF PILOCARPINE HYDROCHLORIDE. Arch NeurPsych. 1935;33(3):478–491. doi:10.1001/archneurpsyc.1935.02250150028003
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