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March 1935


Author Affiliations


From the Neurological Unit, Boston City Hospital, the Department of Neuropathology, Harvard Medical School, and the Cerebrospinal Fluid Laboratory, Massachusetts General Hospital.

Arch NeurPsych. 1935;33(3):516-536. doi:10.1001/archneurpsyc.1935.02250150066006

The cerebrospinal fluid in tuberculous meningitis has been studied since Quincke1 introduced the method of lumbar puncture in 1891. Denigés and Sabrazés,2 in 1896, compared the results of chemical analysis of the cerebrospinal fluid in 2 cases of tuberculous meningitis with the values in a case of rabies and suggested that further study would reveal a formula of the chemical changes in the cerebrospinal fluid characteristic of each infection of the central nervous system. Mestrezat and Gaujoux,3 in 1909, reported findings in 2 cases of tuberculous meningitis confirming the formula of Denigés and Sabrazés.2 Mestrezat,4 in 1912, reported cerebrospinal fluid syndromes in a large number of diseases. With rare exceptions his observations have been confirmed. Mestrezat5 further elaborated these cerebrospinal fluid syndromes on the basis of the physical and chemical characteristics of the fluid.

In 1925, Fremont-Smith and Dailey6 stated: "It should again

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