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May 1935

CAFFEINE SODIOBENZOATE, SODIUM ISO-AMYLETHYL BARBITURATE, SODIUM BROMIDE AND CHLORAL HYDRATEEFFECT ON THE HIGHEST INTEGRATIVE FUNCTIONS

Author Affiliations

NEW YORK; BALTIMORE

From the New York Hospital and the Department of Medicine, Cornell University Medical College, and the Departments of Physiology and Psychiatry, The Johns Hopkins Medical School.

Arch NeurPsych. 1935;33(5):1030-1057. doi:10.1001/archneurpsyc.1935.02250170116009
Abstract

The purpose of this communication is to present a description of the effects of caffeine sodiobenzoate, sodium iso-amylethyl barbiturate, sodium bromide and chloral hydrate on the highest integrative functions. The acquired or conditioned response has been taken as an expression of these functions. For experimental purposes standard methods of testing have been adopted and a measurable component of the conditioned response quantitatively studied. The effects of the aforementioned agents have been compared with other factors that alter responses involving the highest integrative functions.

Animals with a relatively well developed cerebral cortex are characterized as a group by their ability to effect temporary connections between their constantly changing external environment and various activities of their physiologic households. In the broadest terms, it may be said of the group that if there is a coincidence in time of any external stimulus with some activity of the organism, this activity may subsequently be

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