Ten years have elapsed since the introduction of tryparsamide in the treatment of neurosyphilis. After the communication of Lorenz and his associates1 in 1923, the drug was given further trial in various clinics throughout the country. In the course of these ten years a number of reports on the use of tryparsamide as a therapeutic agent in cases of neurosyphilis have appeared, and almost without exception the reports have been favorable. The popularity of tryparsamide may have been overshadowed by the more extensive literature from all parts of the world on malarial treatment of dementia paralytica. While the American literature contains many reports on treatment with tryparsamide, the foreign literature is particularly lacking in reports on the subject. Lichtenstein2 gave a complete bibliography on the subject up to 1931 and emphasized that tryparsamide is still used relatively little in the treatment of neurosyphilis. Therefore, it seems justifiable to
SOLOMON HC, EPSTEIN SH. DEMENTIA PARALYTICA: RESULTS OF TREATMENT WITH TRYPARSAMIDE. Arch NeurPsych. 1935;33(6):1216–1231. doi:10.1001/archneurpsyc.1935.02250180075003
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