Much experimental work has been done on the administration of insulin to nondiabetic subjects. Bulatao and Carlson1 noted that the injection of insulin increased the motility of the stomach in the normal fasting dog. They observed also that subsequent injection of dextrose inhibited this motility. Quigley, Johnson and Solomon2 confirmed these observations and noted an accompanying increase in the sensation of hunger. They concluded that insulin may increase the gastric tone either through a direct action on the gastric mechanism or indirectly through the production of hypoglycemia. This work, the results of which have since been generally confirmed, has established the fact that gastric activity and the level of the blood sugar are intimately associated with the sensation of hunger. Campbell3 wrote: "In intractable anorexia from various causes, hunger may still be induced with insulin when other measures completely fail." Fonseca and de Carvalho,4 Okada and
MUNN C. INSULIN IN CATATONIC STUPOR. Arch NeurPsych. 1935;34(2):262–269. doi:10.1001/archneurpsyc.1935.02250200022002
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