The theory that the malfunction in schizophrenia is due in greater or less degree to decreased oxygenation in the tissues, especially those of the nervous system, has frequently been postulated. That the basal rate of oxygen consumption rate in patients with schizophrenia is decreased is now generally accepted. This failure of the body tissues of the schizophrenic patient to utilize oxygen to the same degree as those of the normal subject might be due either to a deficiency arising in the cells themselves or to a breakdown in the mechanism for delivering oxygen. In the first case, the malfunction might be caused by a lack of oxidative catalysts or a disarrangement of the specific ability of the cells to absorb the oxygen which is supplied to them. In the second case, a number of factors might play a part. The unit concentration of hemoglobin might be decreased through either a
LOONEY JM, FREEMAN H. VOLUME OF BLOOD IN NORMAL SUBJECTS AND IN PATIENTS WITH SCHIZOPHRENIA. Arch NeurPsych. 1935;34(5):956–964. doi:10.1001/archneurpsyc.1935.02250230028002
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