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November 1935

Diffuse Sclerosis: Encephalitis Periaxialis Diffusa.

Arch NeurPsych. 1935;34(5):1131-1132. doi:10.1001/archneurpsyc.1935.02250230203020

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


Bouman, one of the foremost neurologists of Netherlands, has written in English a monograph bringing together a large number of cases of Schilder's disease and allied conditions from the literature and reporting in detail six of his own. There is a fine bibliography at the end, together with a tabulation of cases that serves to emphasize the points that he makes.

In the first place, Bouman states, the classic features of diffuse sclerosis— cortical blindness, mental changes and progressive spasticity—do not hold for all cases, although they may be the terminal state in a large percentage. He considers mental changes to be of outstanding importance and of great significance in differentiating this condition from disseminated sclerosis. Many of the patients found to have diffuse sclerosis have been operated on for suspected tumor, although here again the psychic symptoms are apt to be out of proportion to the symptoms of general

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