Family periodic paralysis is a rare disease of unknown etiology. Reports of cases have appeared in the literature from time to time since Hartwig in 1874 published the first report of an undoubted case of the disease under the title "Intermittent Spinal Paralysis." Singer and Goodbody1 in 1901 summed up the main clinical features of the condition as follows: "Periodic attacks of flaccid paralysis in an otherwise healthy individual, of varying duration from 5 or 6 to 72 hours, during which there is a gradual and progressive onset, leading in complete attacks to absolute paralysis of all four extremities, neck, and trunk but not affecting as a rule the muscles supplied by the cranial nerves. Proceeding pari passu with this loss of power there is loss of muscular excitability to electricity and percussion and abolition of all reflexes in the affected parts. There is never at any time any
Bender JA. FAMILY PERIODIC PARALYSIS IN A GIRL AGED SEVENTEEN. Arch NeurPsych. 1936;35(1):131–135. doi:https://doi.org/10.1001/archneurpsyc.1936.02260010141012
Customize your JAMA Network experience by selecting one or more topics from the list below.