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February 1936


Author Affiliations

Emeritus Professor of Neurology, University of Pennsylvania PHILADELPHIA

From the Neurological Department of the University of Pennsylvania, D. J. McCarthy Foundation.

Arch NeurPsych. 1936;35(2):310-322. doi:10.1001/archneurpsyc.1936.02260020104009

It seems strange that a severe trauma of the head could cause during a period of eighteen years following the event a progressive degeneration of the left pallidum and striatum (putamen and caudatum), amounting to complete destruction of these parts, with the corpus Luysi of the same side; yet this is what I have been able to observe in a patient under my care. Some who examined him made a diagnosis of tumor of the brain because of the progressive development of focal symptoms.

The patient was a man who had been thrown from a rapidly moving motorcycle and had received a severe blow on the head. About three years later the pallidostriatal syndrome began to appear and gradually became severe. The patient lived for about eighteen years after the accident. This traumatic syndrome is compared with those of the extrapyramidal system produced by disease. I shall attempt to show