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March 1936

POLYNEURITIS ASSOCIATED WITH ETHER ANESTHESIA OCCURRING IN THREE MEMBERS OF ONE FAMILY

Author Affiliations

St. Paul, and L. G. Frary, M.D., Minneapolis

From the Department of Nervous and Mental Diseases, University of Minnesota. Medical School.

Arch NeurPsych. 1936;35(3):617-628. doi:10.1001/archneurpsyc.1936.02260030189008
Abstract

Polyneuritis of obscure origin always presents interesting problems. The observations of Wechsler,1 Minot, Strauss and Cobb2 and others on vitamin deficiency, especially deficiency of vitamin B1, as the causative factor have clarified many cases not only from an etiologic but also from a therapeutic standpoint. This theory has been substantiated in a recent study by Jolliffe and Joffe3 on twenty-four alcoholic addicts. They employed Cowgill's4 equation for predicting the vitamin B requirement (referred to as the "Vit/Cal ratio") and found that alcoholic persons having an adequate "Vit/Cal ratio" in the diet did not present neurologic changes even when the consumption of alcohol was continued over a prolonged period. However, alcoholic addicts in whom neuritis developed had an inadequate intake of vitamins, according to the formula, for at least twenty-two days.

Collier5 reported a series of cases of polyneuritis of unknown etiology and stated that

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