Few studies have been made of the lactic acid content of the blood and the cerebrospinal fluid. The measurement of tissue metabolism by Warburg, Lundsgaard, Meyerhof, Himwich,1 Wortis1a and others have emphasized the importance of the rôle of lactic acid in body metabolism. Lactic acid is the main foodstuff for brain tissue, and it therefore seemed important to investigate the content of this substance in the cerebrospinal fluid and in the blood of patients known to have diseases of the central nervous system.
Normally the blood contains between 10 and 25 mg. of lactic acid per hundred cubic centimeters. When the concentration of lactic acid in the blood exceeds the renal threshold of from 30 to 40 mg. per hundred cubic centimeters, it appears in the urine. Moreover, much lactic acid is excreted in the perspiration during violent exercise. Jervell (1928) studied the changes in the lactic acid
WORTIS SB, MARSH F. LACTIC ACID CONTENT OF THE BLOOD AND OF THE CEREBROSPINAL FLUID. Arch NeurPsych. 1936;35(4):717–722. doi:10.1001/archneurpsyc.1936.02260040025002
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