Reexamination of roentgenograms of 6,650 human skulls accumulated over a period of twenty-four years disclosed four types of thickening of the calvaria, named in order of their definiteness: hyperostosis frontalis interna, nebula frontalis, hyperostosis calvariae diffusa and hyperostosis frontoparietalis. The type of thickening which is most characteristic and which led to the study involves the frontal bone, which has on its inner table deposits of new bone with occasional extensions to other bones in the base of the skull. This overgrowth or deposit of cancellous bone lies on the inner table and is covered on its intracranial aspect by a smooth lamella of compact bone. There is no evidence of an inflammatory process. This deposit of bone is increased in density, as seen in roentgenograms. Increase of density progresses from the inner table outwardly through the diploe. The hyperostotic deposit is progressive, and roentgenographically it can be divided into degrees
MOORE S. CALVARIAL HYPEROSTOSIS AND THE ACCOMPANYING SYMPTOM COMPLEX. Arch NeurPsych. 1936;35(5):975–981. doi:10.1001/archneurpsyc.1936.02260050049003
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