Although the phenomenon of forced grasping was described before the classic report of Wilson and Walshe1 in 1914, these authors were the first to associate it with lesions of the frontal lobe. This clinicopathologic deduction received its first experimental confirmation in 1932. Richter and Hines2 were able to produce a "grasp reflex" in adult monkeys by ablation of cortical area 6 of Brodmann, hereinafter referred to as the premotor zone or area. They stated:
In summarizing them the lesion which results in the hanging response on the part of the heterolateral hand is the removal of area 6 anterior to the leg region of the motor cortex through to and including the medial surface. The removal of the comparable area in the opposite hemisphere brings out the reflex in the heterolateral hand as well as the homolateral.
Fulton and his co-workers3 further investigated and elucidated this problem.
WECHSLER IS, BIEBER I, BALSER BH. POSTURAL REFLEXES IN PATIENTS WITH LESIONS OF THE FRONTAL LOBE. Arch NeurPsych. 1936;35(6):1208–1215. doi:10.1001/archneurpsyc.1936.02260060050004
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