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June 1936

GLIOMATOSIS OF THE LEPTOMENINGES

Author Affiliations

Nashville, Tenn.

From the Department of Pathology of the Vanderbilt University Medical School.

Arch NeurPsych. 1936;35(6):1309-1319. doi:10.1001/archneurpsyc.1936.02260060151012
Abstract

Although the earlier literature contains many references to tumors of central nerve tissue characterized by local or extensive invasion of the leptomeninges, now known to be gliomas, methods for a more exact description and classification of such neoplasms based on the differential characteristics of the predominant cell have been employed only in relatively recent work. Originally, and even as late as 1924 and 1926, many of the cases of gliomatosis of the leptomeninges were reported as instances of sarcomatosis of the meninges. With the introduction of adequate staining methods, critical workers began to publish reports of new cases of this type and to restudy the old ones; it has been concluded1 from the information thus acquired that practically all cases of leptomeningeal involvement by small-round-cell (sarcomatous) tumors are examples of gliomatosis, and true sarcomatosis of the meninges is extremely rare.

Before 1926 there had been reported fifty-six cases of

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