Since 1925 the department of pharmacology at the State University of Iowa has been investigating the effect of morphine on tolerant and nontolerant dogs. During the process of addiction of a large series of dogs for these investigations, three died in convulsions, two while on increasing doses and one after withdrawal of the drug. The tissues from two of the animals, prepared by routine histologic technics, were examined by one of us (E. M. MacE.), with negative results (Plant and Pierce1).
On reviewing the literature at that time many papers were found which dealt with the recovery of morphine from tissues, the pharmacologic effects of morphine and the various types of treatment for morphinism, but little was found on the histopathologic picture during acute or chronic morphinism. The reports that were found on the latter phase of the subject concerned chiefly single cases in human beings, without comparison with
MacEWEN EM, BUCHANAN AR. CELLS OF NERVOUS SYSTEM IN ACUTE AND IN CHRONIC MORPHINISM: CORRELATION OF CHANGES WITH BEHAVIOR. Arch NeurPsych. 1936;36(1):112–117. doi:10.1001/archneurpsyc.1936.02260070120009
Customize your JAMA Network experience by selecting one or more topics from the list below.