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A specific epileptic syndrome has been relieved in three instances by lysis of pacchionian granulations. This syndrome is identified clinically by the following features: 1. It is congenital, the illness first manifesting itself in each patient during infancy or early childhood and slowly progressing (in these cases for eighteen, fifty and nineteen years, respectively). 2. The convulsions occurred first in one foot (or leg), and for some years they involved only that one lower extremity, although later the attacks were frequently generalized. 3. There was (in two of the three cases) a slight underdevelopment of the leg or the side of the body where the attacks first started, without, however, any limitation of motion or true paresis of these parts. Associated with this was a slight hyperreflexia.
Cerebral exploration performed on each patient failed to reveal any pathologic lesion of the exposed brain. Electrical stimulation did, however, yield physiologic reactions
SCARFF JE. A SPECIFIC EPILEPTIC SYNDROME RELIEVED BY LYSIS OF PACCHIONIAN GRANULATIONS: PRELIMINARY REPORT OF THREE CASES. Arch NeurPsych. 1936;36(2):373–374. doi:10.1001/archneurpsyc.1936.02260080145009
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