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September 1936

MULTIPLE TELANGIECTASES OF THE BRAIN: A DISCUSSION OF HEREDITARY FACTORS IN THEIR DEVELOPMENT

Author Affiliations

MINNEAPOLIS; BALTIMORE

From the Division of Nervous and Mental Diseases, the Medical School of the University of Minnesota, and the Division of Neurology and Neurosurgery of the University of Chicago.

Arch NeurPsych. 1936;36(3):514-529. doi:10.1001/archneurpsyc.1936.02260090067003
Abstract

The hereditary nature of certain vascular malformations has been established by the familial occurrence of telangiectasis of the skin and mucous membranes (Rendu1 and Osler2). Such abnormalities tend to be widespread and to occur in particular locations in the affected members of a family. The condition has thus been given various names, such as hereditary epistaxis and hereditary hematuria. In a similar way multiple telangiectatic nodules may occur in the central nervous system and also may be hereditary.

We present the report of a family in which several members in two generations suffered from convulsive seizures. In two members multiple calcified lesions were seen in roentgenograms of the skull. Biopsy of one of the nodules revealed calcified and ossified telangiectasis of the brain.

REPORT OF CASES 

Case 1.  —The mother of three of the patients (cases 3, 4 and 5) began to have convulsive seizures at the age

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