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September 1936


Author Affiliations

New York

From the Neurological Service, the Bellevue Hospital and the Department of Neurology, New York University College of Medicine.

Arch NeurPsych. 1936;36(3):601-611. doi:10.1001/archneurpsyc.1936.02260090154012

Melanomatous tumor of the skin or choroid is said to metastasize frequently to the central nervous system, but reports of few cases have been collected in which the pathologic invasion has been accurately studied. In reviewing the records at the Bellevue Hospital we found six cases of melanoma with metastases to the central nervous system. The characteristic life history of such a tumor has been described in previous reports by Fuchs,1 Dawson,2 Bramwell,3 Grant,4 Ewing,5 Globus and Selinsky6 and Bailey.7 It should be emphasized that most of the cases have not been recognized until the postmortem examination, but it appears to us that there are several helpful criteria that should aid in the recognition of the tumor.

The clinical records and the associated pathologic changes in the cases at the Bellevue Hospital follow:

Case 1.  —C. M., a man aged 45, a Puerto