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December 1936

SUBACUTE COMBINED DEGENERATION OF THE SPINAL CORD IN PERNICIOUS ANEMIA: RESULTS OF TREATMENT IN SEVENTY-FOUR CONSECUTIVE CASES WITH CERTAIN CLINICAL OBSERVATIONS

Author Affiliations

TORONTO, CANADA

From the Departments of Medicine and Therapeutics, University of Toronto and Toronto General Hospital.

Arch NeurPsych. 1936;36(6):1166-1205. doi:10.1001/archneurpsyc.1936.02260120013002
Abstract

The efficacy of liver and liver preparations in the treatment for the anemia of Addison's pernicious anemia is generally recognized. The success of this therapy in the relief and prevention of glossitis is well known. It is generally conceded that the gastro-intestinal manifestations, weakness and general symptoms are all relieved by adequate treatment. There are, however, great differences of opinion about the response of the neurologic manifestations to the specific therapy. In 1927 Minot and Murphy1 described definite improvement in the neurologic symptoms in cases in which the condition was of short duration and arrest of the progress of the lesion in others. Similar findings were reported by Graham2 in 1928. Ungley and Suzman3 (1929) described great improvement in the neurologic manifestations in the majority of patients in a group with pernicious anemia associated with subacute combined degeneration of the spinal cord, the less favorable results and

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