The possible cause of residual posttraumatic nervous symptoms has long been the subject of discussion. Variance in opinion as to the origin of these manifestations has given rise to two schools of thought. It is held by one school that such symptoms are largely of psychogenic origin and are the direct result of mental and emotional shock incident to the injury. The second group, on the other hand, believe that posttraumatic manifestations are due predominantly to organic lesions of the brain, although the character and distribution of such lesions have not been clearly established. It was our interest in this question that led us to begin what has proved to be a rather prolonged investigation of the changes in the elements of the brain following severe injury. While it is recognized that a study of morphologic changes could scarcely be expected to explain so variable a clinical picture, it was
RAND CW, COURVILLE CB. HISTOLOGIC STUDIES OF THE BRAIN IN CASES OF FATAL INJURY TO THE HEAD: VI. CYTO-ARCHITECTONIC ALTERATIONS. Arch NeurPsych. 1936;36(6):1277–1293. doi:https://doi.org/10.1001/archneurpsyc.1936.02260120124008
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