Sickle cell anemia is not generally known to be a possible cause of cerebral vascular accident. Recently, I had experience with such a combination of symptoms occurring in a patient whom I observed on his fifth admission to the Charity Hospital because of neurologic symptoms. Although a different diagnosis had been made on each admission, it seems that a careful analysis of this case justifies the conclusion that sickle cell anemia was the cause of the clinical picture.
A search of the literature revealed three cases in which similar manifestations occurred. However, in the reports of these cases there is little, if any, discussion of the relationship of symptoms and signs originating in the central nervous system to the pathologic and clinical aspects of sickle cell anemia. Therefore, this report of a fourth case is given, with an explanation of the probable cause of events in the production of the
R. H. Kampmeier. SICKLE CELL ANEMIA AS A CAUSE OF CEREBRAL VASCULAR DISEASE. Arch NeurPsych. 1936;36(6):1323–1329. doi:10.1001/archneurpsyc.1936.02260120170011