The characteristic pathologic changes uniformly present in the acute stage of vaccinal encephalitis, first seen by Turnbull1 and described by Lucksch,2 encephalitis associated with variola (fig. 1 A), as described by Lucksch, and encephalitis following measles (fig. 1 B), as first described by Wohlwill,3 include a pathologic reaction not recognized before the last decade. This focal change is the perivascular, extra-adventitial and progressive glial reaction and demyelinization which occur along the course of veins for variable distances. In the present study small and large veins were involved but the medium and large vessels presented a marked glial reaction. Study of serial sections stained by the Nissl method showed that the small branches of a vein have no or a minimal glial reaction. As one follows the branch through to vessels of larger caliber the microglial collar about the vein becomes progressively more marked and more widespread. As
FINLEY KH. PERIVENOUS CHANGES IN ACUTE ENCEPHALITIS ASSOCIATED WITH VACCINATION, VARIOLA AND MEASLES. Arch NeurPsych. 1937;37(3):505–513. doi:10.1001/archneurpsyc.1937.02260150035002
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