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March 1937


Author Affiliations


From the Departments of Nervous and Mental Diseases of the Northwestern University Medical School and the Rush Medical College of the University of Chicago, and the Elgin State Hospital.

Arch NeurPsych. 1937;37(3):514-522. doi:10.1001/archneurpsyc.1937.02260150044003

Variations from the normal in body temperature and metabolism have been reported in cases of chronic encephalitis. Wimmer1 and Mazza2 observed febrile and subfebrile temperatures in the disease. Naccarati3 found an increase in metabolism in twenty-five of fortyseven cases of chronic encephalitis and attributed the alterations in the metabolic rate to lesions in the vegetative centers located in the gray substance which surrounds the third ventricle and the aqueduct of Sylvius.

There is considerable experimental evidence that the hypothalamus is the chief heat-regulatory center.4 The question to be answered in the experiments reported in this paper is whether heat regulation is defective in chronic encephalitis.

Rubner,5 among others, demonstrated by calorimetric experiments that the heat production of the body is increased when there is a fall in the external temperature, the body temperature remaining constant. Lavoisier and his associates6 observed that a man consumes