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April 1937

STUDIES IN SCHIZOPHRENIA: CHEMICAL ANALYSES OF BLOOD AND CEREBROSPINAL FLUID

Author Affiliations

BALTIMORE

From the Henry Phipps Psychiatric Clinic, Johns Hopkins Hospital and the Spring Grove State Hospital, Catonsville, Md.

Arch NeurPsych. 1937;37(4):881-894. doi:10.1001/archneurpsyc.1937.02260160181018
Abstract

The purpose of this communication is to report the findings obtained in a study of nineteen different constituents in the cerebrospinal fluid of twenty schizophrenic patients. These data were derived from special investigations of blood and cerebrospinal fluid withdrawn simultaneously and analyzed.

One hardly needs to emphasize the need for examining the blood and the cerebrospinal fluid of schizophrenic patients, because of the scarcity of accurate information in this regard. Nor is it appropriate to reiterate here the reasons outlined elsewhere1 leading to the conclusion that analyses of these fluids, carried out under well determined conditions, allow a more accurate evaluation of the findings.

Taking into consideration that the term schizophrenia, or parergasia, is applied to a wide range and variety of psychotic manifestations and that the kraepelinian classification, for all its convenience, is hardly illuminating, I shall briefly describe the clinical picture presented by each patient and append

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