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April 1937

Syndrome of the Craniospinal Tumor: Symptomatology, Pathology and Treatment.

Arch NeurPsych. 1937;37(4):980-981. doi:10.1001/archneurpsyc.1937.02260160280028

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Extraspinal tumors situated in the foramen occipitale magnum and extending cephalad into the posterior cranial fossa and caudad into the vertebral canal possess, according to Bogorodinski, a sufficiently suggestive clinical picture to justify one in speaking of a special syndrome. For this syndrome Bogorodinski offers the name "craniospinal." Though situated in close proximity both to the medulla and to the cerebellum, craniospinal tumors give no striking, if any, bulbar or cerebellar symptomatology. The syndrome in general varies greatly, depending on the size of the tumor, its relationship to the cranial nerves or spinal cord, the stage of the disease process and other factors. Craniospinal tumors may cause pain (neuralgic stage) and paralysis (hemiplegia, paraplegia, tetraplegia and mixed forms), with or without involvement of cranial nerves or disturbances of sensibility, which on the whole are in marked disproportion to the extent of the motor disturbances. The problem is discussed by Bogorodinski