The occurrence of mental changes in patients having pernicious anemia was noted by Addison1 in his classic description of the disease in 1855. Psychiatric studies of patients with this disease have since appeared only at infrequent intervals, though there are many contributions from an etiologic, neurologic and hematologic standpoint.2 This poverty of psychiatric reports exists in spite of the high incidence of mental changes in this disease, as evidenced by the recent work of Goldhamer and his associates,3 who reported that 64 per cent of their patients showed cerebral symptoms. Other observers, however, reported the incidence of mental changes to be from 25 to 40 per cent; for instance, Ahrens4 reported 25 per cent, Woltman5 39 per cent, Hulett6 35 per cent and Weisenburg7 40 per cent. Mental symptoms in patients with pernicious anemia that are sufficiently severe to be classified as a
HERMAN M, MOST H, JOLLIFFE N. PSYCHOSES ASSOCIATED WITH PERNICIOUS ANEMIA. Arch NeurPsych. 1937;38(2):348–361. doi:10.1001/archneurpsyc.1937.02260200120010
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