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September 1937

POLIOMYELITIS (POLIOMYELOPATHIA) CHRONICA: REPORT OF A CASE, WITH HISTOLOGIC STUDY

Author Affiliations

CLEVELAND

From the Departments of Pathology and Medicine, the City Hospital and the Western Reserve University School of Medicine.

Arch NeurPsych. 1937;38(3):537-549. doi:10.1001/archneurpsyc.1937.02260210103007
Abstract

In 1865 Prevost and Vulpian first described atrophy of the anterior horns and anterior horn cells in infantile paralysis and demonstrated the relation of these changes to the reduction in volume of the white substance and the localization of the disease at a definite level. This led Charcot and Joffroy to the conception of the relationship of amyotrophy to primary disease of the anterior horn cells. Subsequently, Charcot and others pointed out that patients who have survived an attack of acute anterior poliomyelitis may later show progressive spinal muscular atrophy. Spinal nuclear amyotrophies related to trauma, syphilis and diabetes, as well as to preexisting acute poliomyelitis, have been termed poliomyelitis chronica. Salmon and Riley1 found references to fifty-six cases in the literature and reported three additional cases of poliomyelitis chronica in which there was a history of a previous attack of acute poliomyelitis. Only two of these cases were

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