Although patients with muscular disease commonly show some abnormality in the metabolism of creatine and creatinine, the significance of this finding is still obscure. In the present investigations the factors influencing the excretion of creatine and creatinine in various types of muscular disease were studied. In addition, an attempt was made to correlate the results with the pathologic processes in these conditions. The present report gives the findings in twenty patients with progressive muscular dystrophy, representing all stages of the disease. In addition, observations were made on ten other patients with this condition. However, for the sake of brevity, the data on the second series are not presented, as the findings were similar to those reported here. In formulating the conclusions on the significance of the changes in the metabolism of creatine and creatinine in progressive muscular dystrophy, the data on both series have been used, as well as those
MILHORAT AT, WOLFF HG. STUDIES IN DISEASES OF MUSCLE: I. METABOLISM OF CREATINE AND CREATININE IN PROGRESSIVE MUSCULAR DYSTROPHY. Arch NeurPsych. 1937;38(5):992–1024. doi:10.1001/archneurpsyc.1937.02260230090006
Customize your JAMA Network experience by selecting one or more topics from the list below.