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December 1937

A CLINICOPATHOLOGIC STUDY OF ASTROCYTOMAS

Author Affiliations

ANN ARBOR, MICH.

From the Neuropsychiatric Institute, the University of Michigan Medical School, R. W. Waggoner, M.D., Director.

Arch NeurPsych. 1937;38(6):1208-1223. doi:10.1001/archneurpsyc.1937.02260240088007
Abstract

The biologic character of the astrocytoma is little known, although this neoplasm has been treated surgically with some success. Astrocytomas of the cerebrum can be divided into two groups—the bilateral and the unilateral. We wish to demonstrate that it is possible to determine the laws of growth of this tumor and the factors responsible for the bilateral invasion, since the astrocytoma invades and follows the myelinated tracts. Bilateral invasion occurs regularly when the tumor originates in the corpus callosum.

This investigation is limited to astrocytoma of the cerebrum, excluding that of the cerebellum, which represents a different type. The macroscopic study was most important. Weigert sections were used to demonstrate the type and extent of the neoplasm. Histologic examination was valuable in the differentiation of demyelinization resulting from tumor and that produced by edema. Twelve cases will be described.

From the clinical standpoint few definite conclusions can be drawn, and

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