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January 1938


Author Affiliations

Professor of Neurology, the University of Illinois College of Medicine: Attending Neurologist, the Cook County Hospital CHICAGO

From the Division of Neuropathology, the University of Illinois College of Medicine.

Arch NeurPsych. 1938;39(1):116-130. doi:10.1001/archneurpsyc.1938.02270010126011

After Friedreich (18631) described the form of ataxia which bears his name, the clinical and pathologic features of the morbid condition which he established were the subject of much controversy. Thus, Friedreich and Schultze2 considered it a disease of the spinal cord (combined degeneration), while Senator,3 on purely clinical grounds, looked on it as a disease of the cerebellum. Marie in 1893,4 in a review of the cases published under the head of Friedreich's disease, placed some in a separate group, which he designated as heredocerebellar ataxia. In 1900 Dejerine and Thomas5 described olivopontocerebellar atrophy, and in 1909 Léjonne and Lhermitte6 reported a case of so-called olivorubrocerebellar atrophy. The clinical features in the case of Dejerine and Thomas resembled those of both Friedreich's disease and Marie's heredocerebellar ataxia, while in the case described by Léjonne and Lhermitte the clinical picture was mainly that of