Epilepsy may be associated with various injuries of the brain, especially those which affect the parietal or the frontal cortex. Tumors, trauma, scars, degenerations and atrophic conditions have been frequently recorded as concomitant lesions or factors predisposing to convulsive attacks. In the case reported here there were several minor lesions and areas of local atrophy of the premotor cortex on both sides. With these were degenerations of small fiber bundles between the cortex and the thalamus and a small cavity in the left thalamus.
There was a history of long-standing blindness in the right eye. The outstanding observation was a meningioma of the right optic nerve situated at the optic foramen. The tumor compressed the right olfactory region and the neighboring fiber tracts. For a time the convulsive attacks were signalized by an olfactory aura. The clinical history in the case and the variety of anatomic deficiencies associated with the
Papez JW, Rundles RW. A CASE OF EPILEPSY: Associated with Meningioma of the Optic Nerve Sheath, Compressing the Olfactory Centers, Dural Calcifications and Thalamic Lesions. Arch NeurPsych. 1938;39(1):150–158. doi:10.1001/archneurpsyc.1938.02270010160013
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