This monograph by Cecile and Oskar Vogt presents new evidence in favor of the authors' theory of pathoclisis. It is written in a complicated style, but it is beautifully and profusely illustrated and well printed and represents an excellent bit of research in brain physiology.
The Vogts believe not only that specific cerebral structure is associated with specific functions but that specific areas of the brain are associated with certain types of disease processes, the specificity depending on the structure of the brain and on physicochemical processes (pathoclisis). They speak of a general, a specific and a singular type of pathoclisis. General pathoclisis is illustrated by the greater susceptibility to disease of the precentral gyrus and the putamen as compared with that of the nucleus ruber. Specific pathoclisis is seen in the capacity of a part of the brain to react to different processes in the same way. Thus, the
Sitz und Wesen der Krankheiten im Lichte der topistischen Hirnforschung und des Variierens der Tiere. Erster Teil. Befunde der topistischen Hirnforschung als Beitrag zur Lehre von Krankheitssitz. Arch NeurPsych. 1938;39(1):218. doi:10.1001/archneurpsyc.1938.02270010228019
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