In 1932, in a note presented at the Académie de Médecine, I gave the name "cerebral impaludation" to a method which I have employed since 1927 in the treatment of dementia paralytica. This method consists of injecting into the interior of the encephalon a few cubic centimeters of blood containing the malaria organism. This is only one chapter of what I have called "intracerebral therapeutics," therapeutics characterized essentially by the injection of remedies (in the largest sense) into the white substance of the brain.
I conceived this method in the hope of breaking down the encephalolymphatic barrier which opposes the penetration of therapeutic agents into the nerve centers; I have used it since 1925 without success in this respect, however, in the treatment of several patients in my department, especially those with dementia praecox.
Before these experiments, I had tried, with the aid of a steel wire passed through a
DUCOSTE M. CEREBRAL IMPALUDATION. Arch NeurPsych. 1938;40(4):707–716. doi:10.1001/archneurpsyc.1938.02270100079005
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